Francke and Pellegrino (1977) concluded that HLA is distal to 6p21. From study of a 3-generation family segregating for variation of the centromeric heterochromatic region of chromosome 6p11 (6ph), 761421]" pmid="761421"Bakker et al.
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(1989) used a monosomy 6 mutant cell line to establish a molecular map of the MHC region.
Field-inversion gel electrophoresis and Southern blotting techniques were used. Five HTF islands were positioned on the map: between DX (HLA-DQA1; 613503) and DOB, close to DOB; between DRA and C4; between C2 and TNFA, close to C2; within 50 kb telomeric to HLA-C; and within 200 kb telomeric to HLA-A.
(1983) estimated that the genetic distance of HLA from fragile site 6p23 is 20 c M, with a lower 95% probability limit of 8.5 c M, placing HLA proximal to the midpoint of 6p22.
This agreed closely with the other regionalization of HLA at 6p21.3.
(1991) performed fine mapping of the HLA-A subregion of the major histocompatibility complex.